During the 5th World Congress on Targeting Infectious Diseases: Targeting Phage & Antibiotic Resistance 2018 which will be held on October 17-18, 2018 in Florence, Italy, Dr. Mark Sutton, from National Infections Service, Public Health England, United Kingdom, will talk about “Direct phenotypic screening to identify new antimicrobial agents.”
Studies using high throughput screening of compounds have yielded few new drug leads and no commercially viable antibiotics.Using a phenotypic screening cascade with drug resistant and drug sensitive strains we have been able to identify a number of novel antimicrobials.Studies have enabled us to understand the role of bacterial intrinsic resistance, mediated by membrane permeability and efflux, in efficacy of novel compounds. This has enabled us to identify novel strategies for breaking resistance which can be applied to existing and novel compounds.
Don’t hesitate to participate to Targeting Antibiotic Resistance Congress which will be held in Florence on May 17-18, 2018. More information on www.tid-site.com