Joana Azeredo

Dr. Joana Azeredo from CEB – University of Minho, Portugal will talk about “Phage therapy of infectious biofilms” during the 5th World Congress on Targeting Infectious Diseases: Targeting Phage &  Antibiotic Resistance 2018  which will be held on May 17-18, 2018 in Florence, Italy,

According to her: “Acinetobacter baumanni is responsible for the majority and the most difficult to treat nosocomial infections. The World Health Organization considered this species as the number one priority pathogen for the development of new antibiotics. Therefore it is essential that we understand the mechanisms behind the evolution of pathogenicity of this bacterium and also to develop new effective therapeutic approaches. Bacteriophages can be the key answer for these needs. This presentation will focus on the the role of prophages, the “bad guys,  showing their  contribution to enhance A. baumannii host colonization and immune evasion, persistence in adverse conditions, and antibiotic tolerance. Conversely, strictly lytic phages, “good guys” can efficiently kill Acinetobacter strains in suspended cultures, biofilms or even attached to epithelial cells. Besides, these phages’ genomes codify enzymes that can be exploited as antimicrobial agents. I will show that podophages infecting Acinetobacter display structural polysaccharide degrading enzyme essential for host recognition that can be heterologously express and be used to degrade the polysaccharide capsule of the bacterial cells making them less virulence and more easy to kill with antibiotics. I will also show the killing efficacy and stability of a new Acinetobacter endolysin.

Don’t hesitate to participate to Targeting Antibiotic Resistance Congress which will be held in Florence on October 2-3, 2017. More information on www.tid-site.com/