Development of Infection-responsive surface coatings for bacteriophage delivery in the catheterised urinary tract: strategic presentation of Targeting Phage & Antibiotic Resistance Conference

During Targeting Phage & Antibiotic Resistance Conference 2017, Dr Nzakizwanayo from School of Pharmacy and Biomolecular Sciences, University of Brighton, United Kingdom will talk about “Development of Infection-responsive surface coatings for bacteriophage delivery in the catheterised urinary tract”.

According to Dr Nzakizwanayo: “Indwelling urethral catheters (IUC) are widely used for long-term bladder management but are often complicated by acquisition of infection. Proteus mirabilis is a particular problem in this regard, and forms extensive crystalline biofilms on catheter surfaces that obstruct urine flow and lead to serious complications such as pyelonephritis, septicaemia and shock. To address this clinical need, we have developed a novel infection-responsive surface coating for urinary catheters, which responds to elevated pH indicative of P. mirabilis infection. We demonstrate the ability of this coating to provide both a visual early warning of infection, and deliver a therapeutic dose of bacteriophage to control catheter blockage. This potentially “theranostic” coating system is a promising strategy for the deployment of phage therapy and other relevant antimicrobial compounds at local sites within the urinary tract at the exact time when the intervention is needed.”

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