Towards an efficacious treatment: current and future strategies of clinical phage therapy

andrzej gorskiPr. Andrejs Groski, from the Polish Academy of Sciences in Poland is invited as a Key Opinion Leader during Phage Therapy World Congress 2016. 

According to Pr. Gorski, "World leaders, experts and leading  biomedical journals warn that the greatest risk to human health comes in the form of antibiotic resistant bacteria, while WHO declared that the “post-antibiotic era” is on the horizon. In response to this worldwide crisis in 2005 the first center of phage therapy in the EU was established at our Institute which has been treating patients with a wide range of bacterial infections resistant to antibiotics therapy.
The therapy is carried out as a form of experimental treatment (also referred to as compassionate use or expanded access) in accord with the Declaration of Helsinki and  the respective legal and ethical regulations  in effect in Europe and USA. Phage therapy is remarkably safe and can achieve good results in a significant cohort of patients with otherwise untreatable bacterial infections. (...) 
Our recent data also suggest that phage therapy may interfere with viral infections. We envisage that phages armed with organ-specific peptides able to selectively penetrate infected tissues may offer a novel and more efficacious weapon against microbial infections.  Clinical trials and needed to overcome the regulatory hurdles preventing a wider  application of phage therapy which requires much time and funding.  (...)

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